反应条件
1: 1.) Mg, I2, 1,2-dibromoethane / 1.) ether, reflux, 1 h, 2.) ether, 4 h
2: 91 percent / p-TsOH*H2O / toluene / 20 h / Heating
3: 1.) NaBH4, BF3*Et2O, 2.) NaOH, H2O2 / 1.) diglyme, a) 25 deg C, 1 h, b) 160 - 165 deg C, 2.5 h, 2.) diglyme, water, RT, 1.5 h
4: 1.) PPh3, 2.) NBS / 1.) DMF, CH2Cl2, 25 deg C, 10 min, 2.) DMF, CH2Cl2, from -78 to 25 deg C, 2 h
5: 96 percent / dimethylsulfoxide / 1.5 h / 25 °C
6: 1.) n-BuLi, 2.) HMPA / 1.) THF, hexane, from -40 to -30 deg C, 1.5 h, 2.) THF, hexane, 25 deg C, 22 h
7: H2 / 10percent Pd/C
View Scheme
参考文献
Cannon,J.R. et al.
Australian Journal of Chemistry, 1973 , vol. 26, p. 2257 - 2275
