3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
1: triphenylbenzyl-phosphonium bromide With lithium hydroxide in isopropyl alcohol
0.25 h;
2: 3,5-dimethoxy-benzaldehyde in isopropyl alcohol
Wittig reaction; 0.75 h; Heating; Further stages.;
参考文献
Antonioletti; Bonadies; Ciammaichella; Viglianti
Tetrahedron, 2008 , vol. 64, # 20 p. 4644 - 4648
反应条件
in tetrahydrofuran
Wittig reaction;
参考文献
Stefinovic, Marijan; Snieckus, Victor
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2808 - 2809
反应条件
n-butyllithium
1.) THF, hexane, 30 min; 2.) 0 deg C, THF, 30 min; Yield given. Multistep reaction;
参考文献
Mitscher, Lester A.; Park, Young Han; Al-Shamma, Ali; Hudson, P. Bryan; Haas, Thomas
Phytochemistry, 1981 , vol. 20, # 4 p. 781 - 786
反应条件
1: tetrahydrofuran
2: H2 / Pd-C
View Scheme
参考文献
Mitscher, Lester A.; Park, Young Han; Al-Shamma, Ali; Hudson, P. Bryan; Haas, Thomas
Phytochemistry, 1981 , vol. 20, # 4 p. 781 - 786
反应条件
sodium hydroxide in ethanol
Ambient temperature;
参考文献
Ishii; Ishikawa; Deushi; et al.
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3024 - 3038
参考文献
Fillion, Eric; Dumas, Aaron M.; Hogg, Sylvia A.
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9899 - 9902
反应条件
1: 91 percent
2: 90 percent / H2 / Pd/C / ethanol
3: POCl3 / CH2Cl2 / 24 h / Ambient temperature
4: 96 percent / BCl3 / CH2Cl2 / 3 h / Ambient temperature
5: 82 percent / SO2Cl2
6: 91 percent / pyridine / 18 h / Ambient temperature
7: NaClO2, NH3SO3H / tetrahydrofuran; H2O / 5.5 h / Ambient temperature
8: NaOH/H2O / ethanol / 0.75 h / Ambient temperature
View Scheme
参考文献
Green, Richard H.
Tetrahedron Letters, 1997 , vol. 38, # 26 p. 4697 - 4700
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: 80.9 percent / tetrahydrofuran / 6 h
2.1: 77.7 percent / PDC; molecular sieves 4 A / CH2Cl2 / 24 h
View Scheme
参考文献
Pettit, George R.; Grealish, Matthew P.; Jung, M. Katherine; Hamel, Ernest; Pettit, Robin K.; Chapuis, J.-Charles; Schmidt, Jean M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2534 - 2542
反应条件
2: H2 / Pd/C / H2O / pH<7
View Scheme
参考文献
Wenkert,E. et al.
Journal of Organic Chemistry, 1964 , vol. 29, p. 435 - 439
反应条件
1: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
2: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
3: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
