3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
1: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
2: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
3: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
View Scheme
参考文献
NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang
Patent: WO2013/148365 A1, 2013 ;
反应条件
1: HCl; AcOH / 0 °C
2: POCl3 / CHCl3 / Heating
View Scheme
参考文献
Kuhn, Bernd; Hilpert, Hans; Benz, Joerg; Binggeli, Alfred; Grether, Uwe; Humm, Roland; Maerki, Hans Peter; Meyer, Markus; Mohr, Peter
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4016 - 4020
反应条件
1: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
2: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
3: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: acetic acid; chlorine
2: acetic acid; chlorine
3: concentrated aqueous KOH
View Scheme
参考文献
Lock; Nottes
Monatshefte fuer Chemie, 1936 , vol. 68, p. 51,60
反应条件
1: 1.) NaOMe / 1.) DMF, 0 deg C, 30 min, 2.) a) DMF, from 0 deg C to RT, 1.5 h, b) 95-100 deg C, 1 h, c) RT, overnight
2: H2 / 10percent Pd/C / ethyl acetate / 4 h / 2068.6 Torr
View Scheme
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Chakraborti, Asit K.; Lin, Chii M.; Hamel, Ernest
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2579 - 2588
反应条件
1: 75 percent / bromine / acetic acid / 12 h
2: 2.) SOCl2 / 1) THF, 0 deg C, 30 min; 2) THF, 1 h
3: 1.) n-BuLi / 1) THF, hexane, -78 deg C, 1 h; 2) THF, hexane, -78 deg C --> rt
4: SnCl4 / toluene / 0.33 h / 0 °C
5: 95 percent / H2 / Pd/C / ethyl acetate / 72 h
View Scheme
参考文献
Broering, Teresa J.; Morrow, Gary W.
Synthetic Communications, 1999 , vol. 29, # 7 p. 1135 - 1142
反应条件
1: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
2: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
3: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: ethanol; platinum / Hydrogenation
2: pyridine; diethyl ether; SOCl2
3: aqueous ethanol
4: sodium amide; diethyl ether / anschliessend Erwaermen mit Methyljodid
5: diethyl ether / und Erwaermen des vom Aether befreiten Reaktionsgemisches in Benzol, anschliessendes Behandeln mit wss.HCl und Erhitzen der erhaltenen wss.Loesung
View Scheme
参考文献
Adams; Aycock; Loewe
Journal of the American Chemical Society, 1948 , vol. 70, p. 662
反应条件
1: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
2: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
3: ethanethiol, NaH / dimethylformamide / 3 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
ammonium acetate; acetic acid
T=118°C; 1.5 h;
参考文献
De Luca, Laura; De Grazia, Sara; Ferro, Stefania; Gitto, Rosaria; Christ, Frauke; Debyser, Zeger; Chimirri, Alba
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 756 - 764
