3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
potassium hydroxide in methanol; ethanol
T=-8°C; 0.333333 h;
参考文献
Hall, Robin J.; Shannon, Patrick V. R.; Oliveira-Campos, Ana M.-F.; Queiroz, Maria-Joao R. P.
Journal of Chemical Research, Miniprint, 1992 , # 1 p. 114 - 156
反应条件
amberlyst-15 in acetonitrile
1 h;
参考文献
Wiles, Charlotte; Watts, Paul; Haswell, Stephen J.
Tetrahedron Letters, 2007 , vol. 48, # 41 p. 7362 - 7365
反应条件
formaldehyd; ethyl mercaptan sodium salt in N,N-dimethyl-formamide
T=145°C; 1 h;
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter R.
Patent: US2013/281399 A1, 2013 ;
Location in patent: Paragraph 0791; 0797 ;
反应条件
1.1: Mg / tetrahydrofuran / 1 h / Heating
1.2: 93 percent / tetrahydrofuran / -78 - 20 °C
2.1: TMSCl; NaI / acetonitrile; hexane; diethyl ether / 24 h / 20 °C
View Scheme
参考文献
Charalambous, Avgui; Yan, Guo; Houston, Devin B.; Howlett, Allyn C.; Compton, David R.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3076 - 3079
反应条件
(i) nBuLi, Et2O, hexane, (ii) /BRN= 2042374/, Et2O, (iii) H2, Pd-C, EtOH; Multistep reaction;
参考文献
Pitt; Hobbs; Schran; et al.
1975 , vol. 11, # 4 p. 551 - 575
反应条件
1.1: Mg / tetrahydrofuran / 1 h / Heating
1.2: 93 percent / tetrahydrofuran / -78 - 20 °C
2.1: TMSCl; NaI / acetonitrile; hexane; diethyl ether / 24 h / 20 °C
3.1: 1.236 g / BBr3 / CH2Cl2 / 36 h / 20 °C
View Scheme
参考文献
Charalambous, Avgui; Yan, Guo; Houston, Devin B.; Howlett, Allyn C.; Compton, David R.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3076 - 3079
反应条件
1: piperidine; acetic acid; benzene
2: platinum; methanol / Hydrogenation
View Scheme
参考文献
Yagi
Nippon Nogei Kagaku Kaishi, 1955 , vol. 29, p. 198,200
Memoirs of the Institute of Scientific and Industrial Research, Osaka University, 1955 , vol. 12, p. 173
Chem.Abstr., 1959 , p. 303
反应条件
1: acetic acid anhydride; sodium acetate
2: aqueous HI; red phosphorus; acetic acid
View Scheme
参考文献
Lambooy
Journal of the American Chemical Society, 1954 , vol. 76, p. 133,135
反应条件
1: aq. HCl / tetrahydrofuran / -20 °C
2: PCC / CH2Cl2 / 20 °C
3: TiCl4 / CH2Cl2 / -40 °C
View Scheme
参考文献
Krishnamurthy, Mathangi; Ferreira, Antonio M.; Moore II, Bob M.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3487 - 3490
反应条件
1: aq. HCl / tetrahydrofuran / -20 °C
2: PCC / CH2Cl2 / 20 °C
3: TiCl4 / CH2Cl2 / -40 °C
4: BBr3 / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Krishnamurthy, Mathangi; Ferreira, Antonio M.; Moore II, Bob M.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3487 - 3490
