3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
1: phosphorous tribromide / CH2Cl2 / 1 h / Ambient temperature 2: 80 percent / diethyl ether / 30 h / Ambient temperature View Scheme
参考文献
Girard, Michel; Moir, David B.; Apsimon, John W.
Canadian Journal of Chemistry, 1987 , vol. 65, p. 189 - 190
反应条件
1: 127 mg / NaOMe / benzene / 12 h / Ambient temperature 2: 3 mg / tribromoborane / CH2Cl2 / 12 h / Ambient temperature View Scheme
参考文献
Suga, Takayuki; Ohta, Shinji; Munesada, Kiyotaka; Ide, Nagatoshi; Kurokawa, Masako; et al.
Phytochemistry (Elsevier), 1993 , vol. 33, # 6 p. 1395 - 1402
反应条件
1: 97 percent / diethyl ether / 2 h / Ambient temperature 2: 100 percent / Jones reagent / acetone / 0.5 h / Ambient temperature View Scheme
参考文献
Cristol, Stanley J.; Ali, Mahfuza B.; Sankar, Iyer V.
Journal of the American Chemical Society, 1989 , vol. 111, # 21 p. 8207 - 8211
反应条件
1: With Rink resin; trimethyl orthoformate T=25°C; 2 h; 2: With lithium borohydride in tetrahydrofuran T=65°C; 5 h; 3: With trifluoroacetic acid in dichloromethane T=25°C;
参考文献
Yraola, Francesc; Garcia-Vicente, Silvia; Fernandez-Recio, Juan; Albericio, Fernando; Zorzano, Antonio; Marti, Luc; Royo, Miriam
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6197 - 6208
反应条件
1: 72 percent / diethyl ether / 2 h / Heating 2: 73 percent / trifluoroacetic acid; hydrogen / Pd/C / ethanol / 168 h / 2585.74 Torr 3: 100 percent / BBr3 / CH2Cl2 / 0 - 25 °C View Scheme
参考文献
Huffman, John W.; Liddle, John; Duncan Jr., Sammy G.; Yu, Shu; Martin, Billy R.; Wiley, Jenny L.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2383 - 2396
反应条件
1.1: NaOMe / dimethylformamide / 0 °C 1.2: dimethylformamide / 20 °C 2.1: 40 percent / BBr3 / -80 °C View Scheme
参考文献
Ali; Kondo; Tsuda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1130 - 1136
反应条件
1.1: 93 percent / NaBH4 / methanol / 0 °C 2.1: 89 percent / PBr3 / CH2Cl2 / 12 h / 0 °C 3.1: 92 percent / toluene / 12 h / Heating 4.1: n-BuLi / tetrahydrofuran / -78 °C 4.2: tetrahydrofuran 5.1: 88 percent / Bu4NF / tetrahydrofuran / 0.75 h View Scheme
参考文献
Pettit, George R.; Grealish, Matthew P.; Jung, M. Katherine; Hamel, Ernest; Pettit, Robin K.; Chapuis, J.-Charles; Schmidt, Jean M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2534 - 2542
反应条件
1: sodium tetrahydroborate / methanol 2: tetrachloromethane; triphenylphosphine 4: Alkaline conditions View Scheme
参考文献
Jo, Geunhyeong; Hyun, Jiye; Hwang, Doseok; Lee, Young Han; Koh, Dongsoo; Lim, Yoongho
Magnetic Resonance in Chemistry, 2011 , vol. 49, # 6 p. 374 - 377
反应条件
1: 4-(hydroxymethyl)phenyl 4-methylbenzene-1-sulfonate; tripropylphosphine hydrohalide in acetonitrile T=100°C; 8 h; 2: 3,5-dimethoxy-benzaldehyde With lithium hydroxide hydrate in water T=90°C; Wittig Olefination; 12 h; stereoselective reaction;
参考文献
McNulty, James; McLeod, David
Tetrahedron Letters, 2013 , vol. 54, # 47 p. 6303 - 6306
反应条件
acetic anhydride; triethylamine in sodium hydroxide
参考文献
Calyx Therapeutics, Inc.
Patent: US6448450 B1, 2002 ;
