3,5-二甲氧基苯甲醛合成路线 （共 226 条）
反应条件
1: methyl iodide With magnesium in diethyl ether 2: 3,5-dimethoxy-benzaldehyde in diethyl ether Grignard reaction;
参考文献
Roberts, Jeffrey C.; Pincock, James A.
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1480 - 1492
反应条件
magnesium; methyl iodide in diethyl ether 1.) 3 h, reflux; 2.) 1 h, reflux; Yield given;
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; Wittig reaction; 16 h;
参考文献
Zhang; Go
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 6 p. 841 - 850
反应条件
1: p-methoxybenzaldehyde tosyl hydrazone With potassium tert-butylate in toluene T=0 - 20°C; 1 h; 2: 3,5-dimethoxy-benzaldehyde With 5,10,15,20-tetraphenyl porphyrinato iron hydroxide; Aliquatreg; 336; phosphorous acid trimethyl ester in toluene T=40°C; Wittig olefination; 48 h;
参考文献
Journal of the American Chemical Society, , vol. 125, # 20 p. 6034 - 6035
反应条件
1: 4-methoxybenzyl-triphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1.5 h; 2: 3,5-dimethoxy-benzaldehyde in tetrahydrofuran; hexane T=-78 - 20°C; Wittig reaction; 19 h;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6412 - 6415
反应条件
1: 4-methoxybenzyl-triphenylphosphonium bromide With n-butyllithium in tetrahydrofuran T=-78°C; 2 - 4 h; 2: 3,5-dimethoxy-benzaldehyde in tetrahydrofuran 6.5 - 15.5 h;
参考文献
WO2006/45010 A2, ;
Page/Page column 155 ;
WO 2006/045010 A2
反应条件
1: C26H23O4PS With sodium hydroxide in methanol 0.0833333 h; 2: 3,5-dimethoxy-benzaldehyde in methanol T=20°C; Wittig reaction;
参考文献
Journal of Organic Chemistry, , vol. 73, # 21 p. 8583 - 8586
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; Wittig reaction; 16 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 42, # 6 p. 841 - 850
反应条件
in tetrahydrofuran T=-78 - 20°C; Wittig reaction;
参考文献
Journal of Organic Chemistry, , vol. 67, # 13 p. 4627 - 4629
反应条件
sodium hydroxide in dichloromethane; water
参考文献
Magnetic Resonance in Chemistry, , vol. 39, # 12 p. 768 - 770
