2-氨基-苯并[B]噻吩-3-羧酸乙酯合成路线 （共 5 条）
反应条件
pyrrolidine in toluene T=100°C; 8 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/104219 A1, 2003 ;
Location in patent: Page 10; 12-13 ;
WO 03/104219 A1
反应条件
1: With methanesulfonic acid T=20°C; 48 h; 2: With ammonia in water Cooling with ice;
参考文献
Banhegyi, Peter; Gyoergy, Keri; Oerfi, Laszlõ; Szekelyhidi, Zsolt; Waczek, Frigyes
Patent: US2011/15214 A1, 2011 ;
Location in patent: Page/Page column 8 ;
US 20110015214 A1
反应条件
diatomic sulphur; phthalic acid dimethyl ester T=195°C; 8 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/44524 A1, 2006 ;
Location in patent: Page/Page column 54-55 ;
WO 2006/044524 A1
反应条件
1: With sodium hydroxide in tetrahydrofuran; ethanol; water 8 h; Reflux; 2: With hydrogenchloride in water pH=5;
参考文献
Chonan, Tomomichi; Wakasugi, Daisuke; Yamamoto, Daisuke; Yashiro, Miyoko; Oi, Takahiro; Tanaka, Hiroaki; Ohoka-Sugita, Ayumi; Io, Fusayo; Koretsune, Hiroko; Hiratate, Akira
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1580 - 1593
参考文献
Russo, Filippo; Santagati, Andrea; Santagati, Maria; Caruso, Antonina; Leone, Maria Grazia; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 91 - 96
