5-溴-1-苯并噻吩-2-羧酸甲酯合成路线 （共 3 条）
参考文献
BAYER HEALTHCARE AG
Patent: WO2003/104227 A1, 2003 ;
Location in patent: Page 51 ;
参考文献
BAYER HEALTHCARE AG
Patent: WO2003/104227 A1, 2003 ;
Location in patent: Page 51 ;
反应条件
1: 1-bromo-4-methoxy-benzene With tert.-butyl lithium in tetrahydrofuran
T=-78°C; Negishi coupling reaction; 0.5 h;
2: With zinc(II) chloride in tetrahydrofuran
T=-78 - 20°C; Negishi coupling reaction;
3: 5-bromo-1-benzothiophene-2-carboxylic acid methyl ester With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
Negishi coupling reaction; Inert atmosphere;
参考文献
Pinto-Bazurco Mendieta, Mariano A. E.; Negri, Matthias; Hu, Qingzhong; Hille, Ulrike E.; Jagusch, Carsten; Jahn-Hoffmann, Kerstin; Mueller-Vieira, Ursula; Schmidt, Dirk; Lauterbach, Thomas; Hartmann, Rolf W.
Archiv der Pharmazie, 2008 , vol. 341, # 10 p. 547 - 609
