(E)-3-(3,4-二氯苯基)丙烯酸合成路线 （共 17 条）
参考文献
Walling; Wolfstirn
Journal of the American Chemical Society, 1947 , vol. 69, p. 852
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Sprague Electric Co.
Patent: US2406319 , 1943 ;
反应条件
trifluorormethanesulfonic acid T=25°C; 6 h;
参考文献
Rendy, Rendy; Zhang, Yun; McElrea, Aaron; Gomez, Alma; Klumpp, Douglas A.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2340 - 2347
反应条件
1.1: 94 percent / Me3CCOCl; Et3N; LiCl 2.1: Mg / tetrahydrofuran 2.2: 90 percent / CuBr-SMe2 / tetrahydrofuran / -30 - 0 °C 3.1: 91 percent / NaBH4 / tetrahydrofuran; H2O 4.1: PPh3; I2; imidazole 5.1: aq. HCl 6.1: 100 percent / tetrahydrofuran 7.1: 69 percent / t-BuLi / tetrahydrofuran; toluene / -78 °C View Scheme
参考文献
Chen, Cheng-Yi; Reamer, Robert A.
Organic Letters, 1999 , vol. 1, # 2 p. 293 - 294
反应条件
1: SOCl2 / benzene / 0.5 h / 45 - 50 °C 2: CH2Cl2 / 3 h / 0 °C 3: 38 percent / SOCl2 / toluene / Ambient temperature View Scheme
参考文献
Mehta; Musso; White
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 5 p. 443 - 446
反应条件
hydrogenchloride; sodium borohydride in methanol; aqueous potassium hydroxide
参考文献
Rhone-Poulenc Rorer S.A.
Patent: US5677306 A1, 1997 ;
反应条件
hydrogen; palladium on activated charcoal
参考文献
Fuller; Molloy; Day; Roush; Marsh
Journal of medicinal chemistry, 1973 , vol. 16, # 2 p. 101 - 106
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; 3-aminopropionic acid in ethanol
T=20°C; Knoevenagel-Doebner reaction; stereoselective reaction;
参考文献
Zhu, Lingjian; Lei, Ning; Miao, Zhenyuan; Sheng, Chunquan; Zhuang, Chunlin; Yao, Jianzhong; Zhang, Wannian
Chinese Journal of Chemistry, 2012 , vol. 30, # 1 p. 139 - 143
反应条件
sodium acetate; acetic anhydride
T=200°C;
参考文献
Lindenfors
Arkiv foer Kemi, 1959 , vol. 14, p. 227,229
反应条件
trichlorophosphate
T=80 - 90°C; Condensation; Perkin reaction;
参考文献
Simonyan
Pharmaceutical Chemistry Journal, 1999 , vol. 33, # 3 p. 158 - 159
反应条件
piperidine; pyridine
参考文献
Klein; Bergmann
Journal of the American Chemical Society, 1957 , vol. 79, p. 3452
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Jones; Watkinson
Journal of the Chemical Society, 1958 , p. 4064,4068
