(E)-3-(3,4-二氯苯基)丙烯酸合成路线 （共 17 条）
反应条件
sodium methylate; phosphonic acid dimethyl ester
1.) methanol, reflux, 2 h, 2.) 45 min; Multistep reaction;
参考文献
Brittelli, David R.
Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2514 - 2520
参考文献
Sattur; Nargund
Journal of the Karnatak University, 1958 , vol. 3, p. 52
反应条件
1: CuCl2; sodium acetate; H2O / Diazotization
2: bromine; CHCl3
View Scheme
参考文献
Sattur; Nargund
Journal of the Karnatak University, 1958 , vol. 3, p. 52
反应条件
sulfuric acid in ethyl acetate; benzene
参考文献
Pharm-Eco Laboratories, Inc.
Patent: US6268535 B1, 2001 ;
反应条件
AlCl3, aluminium chloride
T=20°C; 23 h;
参考文献
Grimm, Stefanie H.; Allmendinger, Lars; Hoefner, Georg; Wanner, Klaus T.
Chirality, 2013 , vol. 25, # 12 p. 923 - 933
反应条件
trifluorormethanesulfonic acid
T=25°C; 6 h;
参考文献
Rendy, Rendy; Zhang, Yun; McElrea, Aaron; Gomez, Alma; Klumpp, Douglas A.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2340 - 2347
反应条件
1: (COCl)2; DMF / CH2Cl2 / 2 h / 20 °C
2: DIPEA / CH2Cl2 / 0.5 h / 0 - 20 °C
3: CBr4; PPh3 / CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Li, Yue H.; Coppo, Frank T.; Evans, Karen A.; Graybill, Todd L.; Patel, Mehul; Gale, Jennifer; Li, Hu; Tavares, Francis; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5892 - 5896
