N,N,N’,N’-四甲基丙二酰胺合成路线 （共 17 条）
反应条件
1: N,N,N',N'-Tetramethylmalonsaeurediamid With trichlorophosphate T=20°C; 0.5 h; 2: β-naphthol in chlorobenzene T=85°C; 5 h; 3: With sodium acetate in water; chlorobenzene T=80°C; 1.5 h;
参考文献
Sottofattori, Enzo; Anzaldi, Maria; Mazzei, Mauro; Miele, Mariangela; Balbi, Alessandro; Pyshnyi, Dmitri S.; Zakharova, Olga D.; Abramova, Tatyana V.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1515 - 1522
反应条件
triethylamine in tetrahydrofuran
T=70°C; 4 h; Inert atmosphere;
参考文献
Dul, Marie-Claire; Bourgeois, Damien; Maynadie, Jerome; Meyer, Daniel
Tetrahedron Letters, 2013 , vol. 54, # 46 p. 6271 - 6274
反应条件
in methanol; water
T=80°C; 8 h;
参考文献
Malmberg, Wolf-Dieter; Voss, Juergen; Weinschneider, Sabine
Liebigs Annalen der Chemie, 1983 , # 10 p. 1694 - 1711
反应条件
in tetrahydrofuran; pentane
Ambient temperature;
参考文献
Riviere-Baudet; Morere; Dias
Tetrahedron Letters, 1992 , vol. 33, # 43 p. 6453 - 6456
反应条件
1: 2-methoxy-4H-pyrido[1,2-a]pyrimidin-4-one T=850°C; Ring cleavage; P=6E-05 Torr; 4 h;
2: dimethyl amine in diethyl ether; dichloromethane
Addition;
参考文献
Plueg, Carsten; Frank, Wilhelm; Wentrup, Curt
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1999 , # 6 p. 1087 - 1094
反应条件
sodium hydrogencarbonate
参考文献
Janousek,Z.; Viehe,H.G.
Angewandte Chemie, 1971 , vol. 83, p. 615 - 616
参考文献
Pandolfo, Luciano; Bressan, Mario; Paiaro, Gastone
Gazzetta Chimica Italiana, 1986 , vol. 116, # 8 p. 471 - 472
参考文献
Chandra,G. et al.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 2565 - 2568
参考文献
Burgada,R.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1964 , vol. 258, p. 1532 - 1534
反应条件
(i) SOCl2, (ii) /BRN= 605257/, Et2O; Multistep reaction;
参考文献
Bagnall,K.W. et al.
Journal of the Chemical Society [Section] A: Inorganic, Physical, Theoretical, 1966 , p. 741 - 744
