N,N,N’,N’-四甲基丙二酰胺合成路线 （共 17 条）
参考文献
Pandolfo, Luciano; Bressan, Mario; Paiaro, Gastone
Gazzetta Chimica Italiana, 1986 , vol. 116, # 8 p. 471 - 472
反应条件
1: N,N,N',N'-Tetramethylmalonsaeurediamid With trichlorophosphate
T=20°C; 0.5 h;
2: 2-isopropyl-5-methyl-phenol in chlorobenzene
T=110°C; 5 h;
3: With sodium acetate in water; chlorobenzene
T=80°C; 1.5 h;
参考文献
Sottofattori, Enzo; Anzaldi, Maria; Mazzei, Mauro; Miele, Mariangela; Balbi, Alessandro; Pyshnyi, Dmitri S.; Zakharova, Olga D.; Abramova, Tatyana V.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1515 - 1522
反应条件
1: N,N,N',N'-Tetramethylmalonsaeurediamid With trichlorophosphate
T=20°C; 0.5 h;
2: 2-hydroxybiphenyl in chlorobenzene
T=100°C; 4 h;
3: With sodium acetate in water; chlorobenzene
T=80°C; 1.5 h;
参考文献
Sottofattori, Enzo; Anzaldi, Maria; Mazzei, Mauro; Miele, Mariangela; Balbi, Alessandro; Pyshnyi, Dmitri S.; Zakharova, Olga D.; Abramova, Tatyana V.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1515 - 1522
反应条件
1: 48 percent / SeO2 / dioxane / 6 h / Heating
2: 61 percent / P4S10 / 1,2-dimethoxy-ethane / 3 h / 60 °C
View Scheme
参考文献
Malmberg, Wolf-Dieter; Voss, Juergen; Weinschneider, Sabine
Liebigs Annalen der Chemie, 1983 , # 10 p. 1694 - 1711
反应条件
selenium(IV) oxide in 1,4-dioxane
6 h; Heating;
参考文献
Malmberg, Wolf-Dieter; Voss, Juergen; Weinschneider, Sabine
Liebigs Annalen der Chemie, 1983 , # 10 p. 1694 - 1711
反应条件
1: 48 percent / SeO2 / dioxane / 6 h / Heating
2: 56 percent / Lawessons Reagent / 1,2-dimethoxy-ethane / 4 h / 60 °C
View Scheme
参考文献
Malmberg, Wolf-Dieter; Voss, Juergen; Weinschneider, Sabine
Liebigs Annalen der Chemie, 1983 , # 10 p. 1694 - 1711
反应条件
1.1: phosphorus oxychloride / 0.5 h / 20 °C
1.2: chlorobenzene / 5 h / 85 °C
1.3: 71 percent / sodium acetate trihydrate / chlorobenzene; H2O / 1.5 h / 80 °C
2.1: POCl3 / 0.5 h / 20 °C
2.2: 84 percent / 1.5 h / 95 °C
View Scheme
参考文献
Sottofattori, Enzo; Anzaldi, Maria; Mazzei, Mauro; Miele, Mariangela; Balbi, Alessandro; Pyshnyi, Dmitri S.; Zakharova, Olga D.; Abramova, Tatyana V.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1515 - 1522
