4-[(E)-2-(4-甲基苯基)乙烯基]苯胺合成路线 （共 7 条）
反应条件
1,4-dicyclohexyl-diazabutadiene; tetrabutylammomium bromide; caesium carbonate; palladium diacetate in N,N-dimethyl acetamide
T=100°C; Heck reaction; 1 h;
参考文献
Grasa, Gabriela A.; Singh, Rohit; Stevens, Edwin D.; Nolan, Steven P.
Journal of Organometallic Chemistry, 2003 , vol. 687, # 2 p. 269 - 279
反应条件
hydrogenchloride; tin(ll) chloride in acetic acid
Ambient temperature;
参考文献
Hanna, Patrick E.; Gammans, Richard E.; Sehon, Russell D.; Lee, Man-Kil
Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 1038 - 1044
反应条件
1: 88 percent / sodium ethoxide / ethanol / 0.5 h / Ambient temperature
2: 57 percent / SnCl2, concd. HCl / acetic acid / Ambient temperature
View Scheme
参考文献
Hanna, Patrick E.; Gammans, Richard E.; Sehon, Russell D.; Lee, Man-Kil
Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 1038 - 1044
反应条件
1: piperidine / 4 h / 150 - 160 °C
2: hydrazine hydrate / 10 percent Pd/C / CH2Cl2; ethanol / 20 °C
View Scheme
参考文献
Bose, Rohit; Ahmad, Abid R.; Dicks, Andrew P.; Novak, Michael; Kayser, Kelly J.; McClelland, Robert A.
Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 8 p. 1591 - 1599
反应条件
1: piperidine / 4 h / 150 - 160 °C
2: hydrazine hydrate / 10 percent Pd/C / CH2Cl2; ethanol / 20 °C
View Scheme
参考文献
Bose, Rohit; Ahmad, Abid R.; Dicks, Andrew P.; Novak, Michael; Kayser, Kelly J.; McClelland, Robert A.
Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 8 p. 1591 - 1599
反应条件
1: 5 h / 140 °C
2: sodium hydride / tetrahydrofuran / 0.5 h / 50 °C / |Inert atmosphere
3: hydrogenchloride; SnCl2·2H2O / ethanol; water / 7 h / 20 °C / |Reflux
View Scheme
参考文献
Fang, Zhengjun; Cao, Chenzhong; Chen, Guanfan
Journal of Physical Organic Chemistry, 2012 , vol. 25, # 12 p. 1343 - 1350
反应条件
1: Wittig process
2: tin, HCl
View Scheme
参考文献
Yan, Shuxin; Spangler, Lee H.
Journal of Physical Chemistry, 1995 , vol. 99, # 10 p. 3047 - 3052
