4,5-二对甲苯-1,3-二氢咪唑-2-硫酮合成路线 （共 4 条）
反应条件
1: 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide / ethanol / 24 h
2: dimethylformamide / 6 h / Heating
View Scheme
参考文献
Harris, Neil V.; Smith, Christopher; Asthon, Michael J.; Bridge, Andrew W.; Bush, Raymond C.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4384 - 4392
反应条件
in 3-methyl-1-butanol
2 h; Heating;
参考文献
Purushothaman; Rajasekharan Pillai
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 1 p. 18 - 21
反应条件
in N,N-dimethyl-formamide
6 h; Heating;
参考文献
Harris, Neil V.; Smith, Christopher; Asthon, Michael J.; Bridge, Andrew W.; Bush, Raymond C.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4384 - 4392
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=130 - 135°C; 5 h;
参考文献
Meric, Asiye; Incesu, Zerrin; Hatipoglu, Ibrahim
Medicinal Chemistry Research, 2008 , vol. 17, # 1 p. 30 - 41
