反应条件
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / |Reflux; |Large scale
2.1: platinum sulfide on carbon / tetrahydrofuran; water; ethanol / |Reflux; |Large scale
2.2: |Reflux; |Large scale
2.3: 20 °C / |Large scale
3.1: N,N-dimethyl-formamide / 5 °C / |Large scale
View Scheme
参考文献
SANOFI; BAILLON, Bruno; BAULIER, Virginie; COMTE, Myriam; FUGIER, Matthieu; KOZLOVIC, Stéphane; PERRIN, Marc-Antoine
Patent: WO2014/41144 A1, 2014 ;
