1: ortho-fluorobromobenzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran
T=-78°C; 3 h;
2: tri-isopropoxy-borane in tetrahydrofuran
T=-78 - -40°C;
3: With hydrogenchloride in tetrahydrofuran; water
T=20°C;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/65388 A1, 2004 ;
Location in patent: Page 49-50 ;