联硼酸频那醇酯合成路线

参考文献

Jang, Hwanjong; Zhugralin, Adil R.; Lee, Yunmi; Hoveyda, Amir H.
Journal of the American Chemical Society, 2011 , vol. 133, # 20 p. 7859 - 7871

57381-59-65-溴-2-氟苯甲酸甲酯+

73183-34-3联硼酸频那醇酯

872459-87-52-氟-5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)苯甲酸甲酯

参考文献

BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/123680 A1, 2005 ;
Location in patent: Page/Page column 92 ;
WO 2005/123680 A1

26107-79-92-氯-5-(三氟甲基)苯甲酸甲酯+

73183-34-3联硼酸频那醇酯

873846-89-02-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-5-(三氟甲基)苯甲酸甲酯

参考文献

NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/136442 A1, 2006 ;
Location in patent: Page/Page column 90-91 ;
WO 2006/136442 A1

2557-13-33-三氟甲基苯甲酸甲酯+

73183-34-3联硼酸频那醇酯

873846-89-02-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-5-(三氟甲基)苯甲酸甲酯

参考文献

Ishiyama, Tatsuo; Isou, Hironori; Kikuchi, Takao; Miyaura, Norio
Chemical Communications, 2010 , vol. 46, # 1 p. 159 - 161

749927-80-84-溴-2-氟-N,N-二甲基苯甲酰胺+

73183-34-3联硼酸频那醇酯

874289-13-14-(二甲基氨甲酰基)-3-氟苯基硼酸+

1264616-33-2

参考文献

Zhu, Jason; Razler, Thomas M.; Xu, Zhongmin; Conlon, David A.; Sortore, Eric W.; Fritz, Alan W.; Demerzhan, Roman; Sweeney, Jason T.
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 438 - 442

73183-34-3联硼酸频那醇酯+

847818-54-6[2-(4-溴-吡唑-1-基)-乙基]-二甲胺

877149-80-9N,N-二甲基-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑-1-乙胺

参考文献

ORION CORPORATION; LINNANEN, Tero; WOHLFAHRT, Gerd; NANDURI, Srinivas; UJJINAMATADA, Ravi; RAJAGOPALAN, Srinivasan; MUKHERJEE, Subhendu
Patent: WO2013/53983 A1, 2013 ;
Location in patent: Page/Page column 29 ;

877399-34-3+

73183-34-3联硼酸频那醇酯

877399-35-4

参考文献

Cui, J. Jean; Tran-Dube, Michelle; Shen, Hong; Nambu, Mitchell; Kung, Pei-Pei; Pairish, Mason; Jia, Lei; Meng, Jerry; Funk, Lee; Botrous, Iriny; McTigue, Michele; Grodsky, Neil; Ryan, Kevin; Padrique, Ellen; Alton, Gordon; Timofeevski, Sergei; Yamazaki, Shinji; Li, Qiuhua; Zou, Helen; Christensen, James; Mroczkowski, Barbara; Bender, Steve; Kania, Robert S.; Edwards, Martin P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6342 - 6363

878805-73-3+

73183-34-3联硼酸频那醇酯

878805-74-4

参考文献

BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1790650 A1, 2007 ;
Location in patent: Page/Page column 96 ;

845866-82-21-溴-2-二氟甲基苯+

73183-34-3联硼酸频那醇酯

879275-72-62-(2-(二氟甲基)苯基)-4,4,5,5-四甲基-1,3,2-二噁硼烷

参考文献

PFIZER LIMITED
Patent: WO2008/135826 A2, 2008 ;
Location in patent: Page/Page column 157 ;
WO 2008/135826 A2

73183-34-3联硼酸频那醇酯+

339094-04-1

880157-10-8

参考文献

Mita, Yusuke; Noguchi-Yachide, Tomomi; Ishikawa, Minoru; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 3 p. 608 - 617