反应条件
1: 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane; 4-bromo-1H-indazole With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in dimethyl sulfoxide T=80°C; 40 h; Inert atmosphere; 2: 4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in ethanol; toluene T=130°C; Suzuki coupling; 1.5 h; Microwave irradiation;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 18 p. 5522 - 5532
