(E)-甲基3-(4-(氯甲基)苯基)丙烯酸酯合成路线 (共 7 条)
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane
T=0 - 20°C; 4 h;
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.
Patent: WO2004/63169 A1, 2004 ;
Location in patent: Page 101-102 ;
反应条件
triethylamine in dichloromethane
参考文献
Nippon Suisan Kaisha, Ltd.
Patent: US5955505 A1, 1999 ;
US 5955505 A
反应条件
sodium methylate in methanol
参考文献
Jung, Mankil; Lee, Yongnam; Park, Moonsoo; Kim, Hanjo; Kim, Heekyeong; Lim, Eunyoung; Tak, Jungae; Sim, Minjoo; Lee, Dongeun; Park, Namsoo; Oh, Won Keun; Hur, Kyu Yeon; Kang, Eun Seok; Lee, Hyun-Chul
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4481 - 4486
反应条件
in dichloromethane
T=0°C; 0.5 h;
参考文献
Poeylaut-Palena, Andres A.; Testero, Sebastian A.; Mata, Ernesto G.
Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 2024 - 2027
反应条件
1: 87 percent / K2CO3 / acetone
2: 91 percent / DIBAL-H / CH2Cl2 / -78 °C
3: 90 percent / PCC / CH2Cl2 / 0 °C
4: 91 percent / NaOCH3 / methanol
View Scheme
参考文献
Jung, Mankil; Lee, Yongnam; Park, Moonsoo; Kim, Hanjo; Kim, Heekyeong; Lim, Eunyoung; Tak, Jungae; Sim, Minjoo; Lee, Dongeun; Park, Namsoo; Oh, Won Keun; Hur, Kyu Yeon; Kang, Eun Seok; Lee, Hyun-Chul
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4481 - 4486
反应条件
1: 91 percent / DIBAL-H / CH2Cl2 / -78 °C
2: 90 percent / PCC / CH2Cl2 / 0 °C
3: 91 percent / NaOCH3 / methanol
View Scheme
参考文献
Jung, Mankil; Lee, Yongnam; Park, Moonsoo; Kim, Hanjo; Kim, Heekyeong; Lim, Eunyoung; Tak, Jungae; Sim, Minjoo; Lee, Dongeun; Park, Namsoo; Oh, Won Keun; Hur, Kyu Yeon; Kang, Eun Seok; Lee, Hyun-Chul
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4481 - 4486
反应条件
1: 90 percent / PCC / CH2Cl2 / 0 °C
2: 91 percent / NaOCH3 / methanol
View Scheme
参考文献
Jung, Mankil; Lee, Yongnam; Park, Moonsoo; Kim, Hanjo; Kim, Heekyeong; Lim, Eunyoung; Tak, Jungae; Sim, Minjoo; Lee, Dongeun; Park, Namsoo; Oh, Won Keun; Hur, Kyu Yeon; Kang, Eun Seok; Lee, Hyun-Chul
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4481 - 4486