4-甲氧基-4-连苯基羧酸乙酯合成路线 （共 49 条）
反应条件
1: 4-amino-benzoic acid ethyl ester With tert.-butylnitrite; boron trifluoride diethyl etherate in methanol T=0°C; 0.5 h; Schlenk technique; 2: (4-methoxyphenyl)-boronic acid in methanol T=0 - 60°C; 5 h; Schlenk technique;
参考文献
Zong, Yan; Hu, Jiefeng; Sun, Peipei; Jiang, Xiaoqing
Synlett, 2012 , vol. 23, # 16 art. no. ST-2012-W0506-L, p. 2393 - 2396
反应条件
1-ethyl-2-pyrrolidinone; 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride; zinc dibromide in tetrahydrofuran T=20°C; 1 h;
参考文献
knochel, Paul; Gavriushin, Andrei; Kofink, Christiane Charlotte; Manolikakes, Georg
Patent: US2010/184977 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
potassium phosphate; [5-(3-butylbenzimidazol-2-yliden-1-yl)-25,26,27,28-tetrapropyloxy calix[4]arene] (pyridine) palladium(II) dibromide in 1,4-dioxane T=100°C; 24 h; Inert atmosphere;
参考文献
Ren, Hui; Xu, Yong; Jeanneau, Erwann; Bonnamour, Isabelle; Tu, Tao; Darbost, Ulrich
Tetrahedron, 2014 , vol. 70, # 17 p. 2829 - 2837
反应条件
1: 4-bromo-benzoic acid ethyl ester With cobalt(II) dibromide; zinc dibromide; zinc; bromobenzene; trifluoroacetic acid in acetonitrile T=20°C; 0.5 h; 2: para-iodoanisole With bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=20°C;
参考文献
Fillon, Hyacinthe; Gosmini, Corinne; Perichon, Jacques
Journal of the American Chemical Society, 2003 , vol. 125, # 13 p. 3867 - 3870
反应条件
bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; 1,4-di(diphenylphosphino)-butane in toluene T=90°C; 24 h;
参考文献
Denmark, Scott E.; Ober, Michael H.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1703 - 1714
反应条件
1-ethyl-2-pyrrolidinone; 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride; zinc dibromide in tetrahydrofuran T=20°C; 48 h;
参考文献
Gavryushin, Andrei; Kofink, Christiane; Manolikakes, Georg; Knochel, Paul
Organic Letters, 2005 , vol. 7, # 22 p. 4871 - 4874
反应条件
manganese; cobalt (II) bromide; triphenylphosphine; trifluoroacetic acid in pyridine; N,N-dimethyl-formamide T=50°C;
参考文献
Amatore, Muriel; Gosmini, Corinne
Angewandte Chemie - International Edition, 2008 , vol. 47, # 11 p. 2089 - 2092
反应条件
1: 4-iodobenzoic acid ethyl ester With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-20°C; 0.5 h; Inert atmosphere; 2: 1-bromo-4-methoxy-benzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in tetrahydrofuran T=25°C; Kumada coupling reaction; 0.0833333 h; Inert atmosphere;
参考文献
Manolikakes, Georg; Knochel, Paul
Angewandte Chemie - International Edition, 2009 , vol. 48, # 1 p. 205 - 209
反应条件
1: p-methoxy-phenylmagnesium chloride With zinc dibromide in tetrahydrofuran; ethylpyrrolidin-2-one; 1- Inert atmosphereSchlenk tubeCooling; 2: 4-bromo-benzoic acid ethyl ester With 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride in tetrahydrofuran; ethylpyrrolidin-2-one; 1- T=20°C; 48 h; Schlenk tubeInert atmosphere; 3: With ammonium chloride in tetrahydrofuran; ethylpyrrolidin-2-one; 1- Product distribution / selectivity;
参考文献
knochel, Paul; Gavriushin, Andrei; Kofink, Christiane Charlotte; Manolikakes, Georg
Patent: US2010/184977 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
1: 4-amino-benzoic acid ethyl ester With tetrafluoroboric acid; sodium nitrite in water T=0 - 5°C; Diazotization; 0.5 h; 2: 4-MeOC4H6BF3K With palladium diacetate in 1,4-dioxane T=20°C; Arylation; 2 h;
参考文献
Darses, Sylvain; Michaud, Guillaume; Genet, Jean-Pierre
European Journal of Organic Chemistry, 1999 , # 8 p. 1875 - 1883
