3,5-二氯-2,6-二甲氧基苯甲酸合成路线 （共 9 条）
反应条件
sulfuryl dichloride in chloroform 0.5 h; Heating;
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
potassium hydroxide in water; dimethyl sulfoxide T=80 - 90°C; 24 h;
参考文献
Elix, John A.; Portelli, Victor J.
Australian Journal of Chemistry, 1990 , vol. 43, # 10 p. 1773 - 1778
反应条件
1: 61 percent / sulfuryl chloride / diethyl ether / 2 h / Ambient temperature 2: 90 percent / K2CO3 / acetone / 16 h / Ambient temperature 3: 78 percent / KOH / H2O; dimethylsulfoxide / 24 h / 80 - 90 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 43, # 10 p. 1773 - 1778
反应条件
1: 90 percent / K2CO3 / acetone / 16 h / Ambient temperature 2: 78 percent / KOH / H2O; dimethylsulfoxide / 24 h / 80 - 90 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 43, # 10 p. 1773 - 1778
反应条件
1: SOCl2 / toluene; dimethylformamide / 2 h / 60 °C 2: 3.13 g / CH2Cl2 / 20 °C 3: 71 percent / BBr3 / CH2Cl2 / -20 - 20 °C View Scheme
参考文献
Fei, Xiangshu; Mock, Bruce H.; DeGrado, Timothy R.; Wang, Ji-Quari; Glick-Wilson, Barbara E.; Sullivan, Michael L.; Hutchins, Gary D.; Zheng, Qi-Huang
Synthetic Communications, 2004 , vol. 34, # 10 p. 1897 - 1907
反应条件
thionyl chloride; N,N-dimethyl-formamide in chloroform 1 h; Heating;
参考文献
Elix, John A.; Portelli, Victor J.
Australian Journal of Chemistry, 1990 , vol. 43, # 10 p. 1773 - 1778
反应条件
thionyl chloride in diethyl ether; water; toluene
参考文献
Astra Lakemedel Aktiebolag
Patent: US4232037 A1, 1980 ;
US 4232037 A
反应条件
1: SOCl2 / 0.23 h / Heating
2: butan-2-one / 2 h / Ambient temperature
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
iodine; mercury(II) oxide in nitrobenzene
T=160 - 165°C; 2 h;
参考文献
Karimi, Farhad; Langstroem, Bengt
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 20 p. 2256 - 2259
