3-溴-5-氯-2,6-二甲氧基苯甲酸合成路线 （共 6 条）
反应条件
bromine; sodium acetate in acetic acid
Ambient temperature;
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
sulfuryl dichloride in chloroform
1.) RT, 12 h, 2.) reflux, 45 min;
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: 78 percent / SOCl2 / CHCl3 / 0.5 h / 50 °C
2: 17 percent / Br2, AcONa / acetic acid / Ambient temperature
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
sodium hydroxide; thionyl chloride in water; toluene; butanone
参考文献
Astra Lakemedel Aktiebolag
Patent: US4232037 A1, 1980 ;
US 4232037 A
反应条件
1: SOCl2 / 1 h / Heating
2: butan-2-one / 0.5 h
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
thionyl chloride
1 h; Heating;
参考文献
de Paulis; Kumar; Johansson; Raemsby; Hall; Saellemark; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 61 - 69
