2-(2-氯-2-丙烯-1-基)苯甲酸合成路线 （共 2 条）
反应条件
1: With sodium hydroxide in methanol; water
T=20°C; 20 h;
2: With hydrogenchloride in water
pH=2;
参考文献
Linghu, Xin; McLaughlin, Mark; Chen, Cheng-Yi; Reamer, Robert A.; Dimichele, Lisa; Davies, Ian W.
Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1550 - 1552
反应条件
1.1: iso-propylmagnesium bromide / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere
1.2: 0.08 h / -40 °C / Inert atmosphere
1.3: -40 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / methanol; water / 20 h / 20 °C
2.2: pH 2
View Scheme
参考文献
Linghu, Xin; McLaughlin, Mark; Chen, Cheng-Yi; Reamer, Robert A.; Dimichele, Lisa; Davies, Ian W.
Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1550 - 1552
