2-甲基-2-丙基2-[(乙酰基硫基)甲基]-1-吡咯烷羧酸酯合成路线 （共 13 条）
反应条件
water in N,N-dimethyl-formamide
T=65°C; 3 h;
参考文献
Yang, Renliang; Qi, Le; Liu, Yanling; Ding, Yingjie; Kwek, Milton Sheng Yi; Liu, Chuan-Fa
Tetrahedron Letters, 2013 , vol. 54, # 29 p. 3777 - 3780
反应条件
1: 90 percent / pyridine / 0 °C
2: 88 percent / ethanol / Heating
View Scheme
参考文献
Cran; Gibson; Handa
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1553 - 1556
反应条件
1: 99 percent / CH2Cl2 / 0.5 h
2: Et3N / CH2Cl2 / 0.5 h / 0 °C
3: LiBr / tetrahydrofuran / 20 h / Heating
4: 54 percent / KOH / ethanol / 1.) RT, 30 min, 2.) reflux, 4 h
View Scheme
参考文献
Dae Yoon Chi; O'Neil; Anderson; Welch; Katzenellenbogen
Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 928 - 937
反应条件
1: 99 percent / CH2Cl2 / 0.5 h
2: Et3N / CH2Cl2 / 0.5 h / 0 °C
3: LiBr / tetrahydrofuran / 20 h / Heating
4: 54 percent / KOH / ethanol / 1.) RT, 30 min, 2.) reflux, 4 h
View Scheme
参考文献
Dae Yoon Chi; O'Neil; Anderson; Welch; Katzenellenbogen
Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 928 - 937
反应条件
1: LiBr / tetrahydrofuran / 20 h / Heating
2: 54 percent / KOH / ethanol / 1.) RT, 30 min, 2.) reflux, 4 h
View Scheme
参考文献
Dae Yoon Chi; O'Neil; Anderson; Welch; Katzenellenbogen
Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 928 - 937
参考文献
Chi, Dae Yoon; Katzenellenbogen, John A.
Journal of the American Chemical Society, 1993 , vol. 115, # 15 p. 7045 - 7046
反应条件
potassium hydroxide in ethanol
1.) RT, 30 min, 2.) reflux, 4 h;
参考文献
Dae Yoon Chi; O'Neil; Anderson; Welch; Katzenellenbogen
Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 928 - 937
参考文献
Cran; Gibson; Handa
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1553 - 1556
反应条件
1: 86 percent / LiAlH4 / diethyl ether / 0 °C
2: 90 percent / pyridine / 0 °C
3: 88 percent / ethanol / Heating
View Scheme
参考文献
Cran; Gibson; Handa
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1553 - 1556
反应条件
1: Et3N
2: 86 percent / LiAlH4 / diethyl ether / 0 °C
3: 90 percent / pyridine / 0 °C
4: 88 percent / ethanol / Heating
View Scheme
参考文献
Cran; Gibson; Handa
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1553 - 1556
