N-3-[3-(1-哌啶甲基)-苯氧基]丙胺合成路线 （共 18 条）
反应条件
1: 95.5 percent / K2CO3 / CH2Cl2 / 0.5 h / 0 - 5 °C 2: 70.3 percent / dimethylformamide / 1 h / 90 °C View Scheme
参考文献
Tarpanov, Velichko; Vlahov, Radoslav; Penkov, Miho; Krikorian, Dikran; Parushev, Stoyan; Mechkarova, Pepa; Angelova, Nely; Schunack, Walter
Synthetic Communications, 1999 , vol. 29, # 1 p. 15 - 20
反应条件
sodium hydroxide; triethylamine in benzene
参考文献
Snow Brand Milk Products Co., Ltd.
Patent: US5317026 A1, 1994 ;
参考文献
Teikoku Hormone Mfg. Co., Ltd.
Patent: US4293557 A1, 1981 ;
反应条件
1: 100 percent / N,O-bis(trimethylsilyl)acetamide / CH2Cl2 / 0.5 h / Ambient temperature 2: 82 percent / 85percent KOH / methanol / 1 h / Ambient temperature View Scheme
参考文献
Ueda; Ishii; Shinozaki; Seiki; Arai; Hatanaka
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 11 p. 3035 - 3041
反应条件
in toluene 15 h; Heating;
参考文献
Ueda; Ishii; Shinozaki; Seiki; Arai; Hatanaka
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 11 p. 3035 - 3041
反应条件
in ethanol 2.5 h; Ambient temperature;
参考文献
Miyashita; Matsumoto; Matsukubo; Iinuma; Taga; Sekiguchi; Hamada; Okamura; Nishino
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2446 - 2451
反应条件
1: 94 percent / ethanol / 1 h
2: 85 percent / methanol / Ambient temperature
3: NH2NH2*H2O / ethanol / 48 h
View Scheme
参考文献
Wegner
Archiv der Pharmazie, 1985 , vol. 318, # 4 p. 377 - 380
参考文献
Wegner
Archiv der Pharmazie, 1985 , vol. 318, # 4 p. 377 - 380
