反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 98.5 h / 0 - 20 °C
2: copper(l) iodide / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
3: pyridine / 26 h / -10 - 25 °C / |Inert atmosphere
4: Novozym 435 / tert-butyl alcohol; aq. phosphate buffer / 192 h / 20 °C / pH 7 / |Resolution of racemate; |Enzymatic reaction
View Scheme
参考文献
Faigl, Ferenc; Kovacs, Ervin; Balogh, Dora; Holczbauer, Tamas; Czugler, Matyas; Simandi, Bela
Central European Journal of Chemistry, 2014 , vol. 12, # 1 p. 25 - 32
