lithium diisopropyl amide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane T=-78 - 20°C; 1.5 h;

1: LDA / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -78 - 0 °C 2: 2.5 g / LDA / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1.5 h / -78 - 20 °C View Scheme

lithium diisopropyl amide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane 1.) -78 deg C, 10 min, 2.) r.t., 1.5 h; Yield given;

Yield given. Multistep reaction;