2-[4-(3-甲基丁-2-烯基)苯基]丙酸合成路线 （共 7 条）
反应条件
sodium hydroxide in ethanol; water
4 h; Ambient temperature;
参考文献
Amano, Takehiro; Yoshikawa, Kensei; Sano, Tatsuhiko; Ohuchi, Yutaka; Shiono, Manzo; et al.
Synthetic Communications, 1986 , vol. 16, # 5 p. 499 - 508
反应条件
sodium hydroxide in methanol
Heating;
参考文献
Amano, Takehiro; Yoshikawa, Kensei; Sano, Tatsuhiko; Ohuchi, Yutaka; Shiono, Manzo; et al.
Synthetic Communications, 1986 , vol. 16, # 5 p. 499 - 508
参考文献
Taisho Pharmaceutical Company, Ltd.
Patent: US4433160 A1, 1984 ;
反应条件
1: 1.) magnesium, 2.) copper(I) bromide / 1.) THF, 110-120 deg C, 7 h, 2.) room temperature, 1 h, 3.) reflux, 1 h
2: 93 percent / sodium hydroxide / methanol / Heating
View Scheme
参考文献
Amano, Takehiro; Yoshikawa, Kensei; Sano, Tatsuhiko; Ohuchi, Yutaka; Shiono, Manzo; et al.
Synthetic Communications, 1986 , vol. 16, # 5 p. 499 - 508
反应条件
nickel dichloride in tetrahydrofuran
15-20 deg C, 5 h then -20 deg C;
参考文献
Amano, Takehiro; Ota, Tomomi; Yoshikawa, Kensei; Sano, Tatsuhiko; Ohuchi, Yutaka; et al.
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 5 p. 1656 - 1658
反应条件
1: 67 percent / tetrahydrofuran / 1.) 10-15 deg C, 2 h; 2.) r.t.;
2: 1.) magnesium, 1,2-dibromoethane, iodine; 2.) NiCl2 / 1.) THF, 100-110 deg C, 2 h; 2.) THF r.t., 4.5 h
3: 93 percent / NaOH / ethanol; H2O / 6 h / Ambient temperature
View Scheme
参考文献
Amano; Yoshikawa; Ogawa; Sano; Ohuchi; Tanami; Ota; Hatayama; Higuchi; Amanuma
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 11 p. 4653 - 4662
反应条件
1: 67 percent / tetrahydrofuran / 1.) 10-15 deg C, 2 h; 2.) r.t.;
2: 1.) magnesium, 1,2-dibromoethane, iodine; 2.) NiCl2 / 1.) THF, 100-110 deg C, 2 h; 2.) THF r.t., 4.5 h
3: 93 percent / NaOH / ethanol; H2O / 6 h / Ambient temperature
View Scheme
参考文献
Amano; Yoshikawa; Ogawa; Sano; Ohuchi; Tanami; Ota; Hatayama; Higuchi; Amanuma
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 11 p. 4653 - 4662
