4-(乙氧基-羟基磷酰)氧基庚烷-2,3,4-三羧酸合成路线 （共 6 条）
反应条件
1: With trimethylsilyl bromide; sodium hydrogencarbonate in acetonitrile
T=20°C; 2 h;
2: With methanol in acetonitrile
T=20°C; 1 h;
参考文献
Turhanen, Petri A.; Demadis, Konstantinos D.; Peraeniemi, Sirpa; Vepsaelaeinen, Jouko J.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1468 - 1471
反应条件
1.1: 100 percent Spectr. / Et3N / diethyl ether / 24 h / 20 °C
2.1: Et3N / diethyl ether / 20 °C
3.1: SO2Cl2 / diethyl ether / 1 h / 20 °C
4.1: 100 percent / NaHCO3 / H2O / 1 h / 20 °C
5.1: Me3SiBr; NaHCO3 / acetonitrile / 2 h / 20 °C
5.2: MeOH / acetonitrile / 1 h / 20 °C
View Scheme
参考文献
Turhanen, Petri A.; Demadis, Konstantinos D.; Peraeniemi, Sirpa; Vepsaelaeinen, Jouko J.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1468 - 1471
反应条件
ethanol; platinum
Hydrogenation;
参考文献
Meyer et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2094
反应条件
1.1: Et3N / diethyl ether / 20 °C
2.1: SO2Cl2 / diethyl ether / 1 h / 20 °C
3.1: 100 percent / NaHCO3 / H2O / 1 h / 20 °C
4.1: Me3SiBr; NaHCO3 / acetonitrile / 2 h / 20 °C
4.2: MeOH / acetonitrile / 1 h / 20 °C
View Scheme
参考文献
Turhanen, Petri A.; Demadis, Konstantinos D.; Peraeniemi, Sirpa; Vepsaelaeinen, Jouko J.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1468 - 1471
反应条件
1.1: 100 percent / NaHCO3 / H2O / 1 h / 20 °C
2.1: Me3SiBr; NaHCO3 / acetonitrile / 2 h / 20 °C
2.2: MeOH / acetonitrile / 1 h / 20 °C
View Scheme
参考文献
Turhanen, Petri A.; Demadis, Konstantinos D.; Peraeniemi, Sirpa; Vepsaelaeinen, Jouko J.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1468 - 1471
反应条件
sodium hydroxide
Hydrogenation;
参考文献
Meyer et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2094
