叔丁基 3-甲基-6,7-二氢-1H-吡唑并[4,3-c]吡啶-5(4H)-羧酸合成路线 （共 5 条）
反应条件
hydrazine in ethanol; water
T=90°C; 2 h; Reflux;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
Location in patent: Paragraph 00388 ;
反应条件
1.1: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C
2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C
3.2: 7 h / -78 °C
4.1: hydrazine / water; ethanol / 2 h / 90 °C / |Reflux
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C
2.2: 7 h / -78 °C
3.1: hydrazine / water; ethanol / 2 h / 90 °C / |Reflux
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1.1: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C
2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C
3.2: 7 h / -78 °C
4.1: hydrazine / water; ethanol / 2 h / 90 °C / |Reflux
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C
1.2: 7 h / -78 °C
2.1: hydrazine / water; ethanol / 2 h / 90 °C / |Reflux
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
