6-(2,4-二甲氧基苯基)烟酸合成路线 (共 1 条)
反应条件
1: 6-chloro-nicotinic acid With tritylchloride-polystyrene resin; N-ethyl-N,N-diisopropylamine in dichloromethane; N,N-dimethyl-formamide
T=20°C; 18 h;
2: 2,4-dimethoxybenzeneboronic acid With potassium phosphate; phenyl-phospha-adamantane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran; water
T=20°C; solid-phase Suzuki coupling; 15 h;
3: With trifluoroacetic acid in dichloromethane
T=20°C; 1.5 h; Further stages.;
参考文献
Ohnmacht, Stephan A.; Brenstrum, Tim; Bleicher, Konrad H.; McNulty, James; Capretta, Alfredo
Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5661 - 5663