(2S,3S)-3-(Boc-氨基)-2-羟基-5-甲基己酸合成路线 （共 13 条）
反应条件
triethylamine in tetrahydrofuran; trans-1,3-dioxane; water T=20°C; 40 h;
参考文献
EP1192162 B1, ;
Page 4; 14-16 ;
反应条件
1: H2 / 5percent Pd/BaSO4 / xylene / 6 h / 110 °C 2: 100 percent / ZnI2 / CH2Cl2 / 12 h / Ambient temperature 3: 10percent aq. HCl / 1.5 h 4: 6 N aq. HCl / dioxane / 48 h / Heating 5: 100 percent / NEt3 / H2O; dioxane / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 5 p. 605 - 610
反应条件
1: SOCl2 / benzene / 6 h / Heating 2: H2 / 5percent Pd/BaSO4 / xylene / 6 h / 110 °C 3: 100 percent / ZnI2 / CH2Cl2 / 12 h / Ambient temperature 4: 10percent aq. HCl / 1.5 h 5: 6 N aq. HCl / dioxane / 48 h / Heating 6: 100 percent / NEt3 / H2O; dioxane / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 5 p. 605 - 610
反应条件
1: 100 percent / NEt3 / H2O; dioxane / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 5 p. 605 - 610
反应条件
1: 6 N aq. HCl / dioxane / 48 h / Heating 2: 100 percent / NEt3 / H2O; dioxane / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 5 p. 605 - 610
反应条件
1: 10percent aq. HCl / 1.5 h 2: 6 N aq. HCl / dioxane / 48 h / Heating 3: 100 percent / NEt3 / H2O; dioxane / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 5 p. 605 - 610
反应条件
1: 100 percent / ZnI2 / CH2Cl2 / 12 h / Ambient temperature 2: 10percent aq. HCl / 1.5 h 3: 6 N aq. HCl / dioxane / 48 h / Heating 4: 100 percent / NEt3 / H2O; dioxane / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 5 p. 605 - 610
反应条件
sodium hydroxide; water
参考文献
Journal of Organic Chemistry, , vol. 45, # 12 p. 2288 - 2290
反应条件
1: Et3N / methanol / 20 °C 2: LiOH*H2O / ethanol View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 6 p. 1862 - 1870
反应条件
1: triethylamine 3: water, sodium hydroxide View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 12 p. 2288 - 2290
