4-(羟甲基)苯醋酸合成路线

13737-36-54-(溴甲基)苯乙酸

73401-74-84-(羟甲基)苯醋酸

参考文献

Sankyo Company, Limited
Patent: US5534529 A1, 1996 ;

73401-74-84-(羟甲基)苯醋酸

96524-70-8对甲酰基苯基乙酸甲酯

参考文献

CHIESI FARMACEUTICI S.P.A.; RANCATI, Fabio; LINNEY, Ian
Patent: WO2014/86924 A1, 2014 ;

67-56-1甲醇+

73401-74-84-(羟甲基)苯醋酸

155380-11-34-(羟基甲基)苯乙酸甲酯

参考文献

ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/149997 A1, 2013 ;
Location in patent: Page/Page column 46; 47 ;

73401-74-84-(羟甲基)苯醋酸+

18107-18-1三甲基硅烷化重氮甲烷

155380-11-34-(羟基甲基)苯乙酸甲酯

参考文献

AERIE PHARMACEUTICALS, INC.; DELONG, Mitchell, A.; STURDIVANT, Jill, Marie; ROYALTY, Susan, M.; HEINTZELMAN, Geoffrey, Richard; YINGLING, Jeffrey, D.; KOPCZYNSKI, Casey
Patent: WO2010/127329 A1, 2010 ;
Location in patent: Page/Page column 54 ;
WO 2010/127329 A1

73401-74-84-(羟甲基)苯醋酸

34841-47-92-(4-甲酰基苯基)乙酸

参考文献

CHROMA THERAPEUTICS LTD.
Patent: WO2008/40934 A1, 2008 ;
Location in patent: Page/Page column 72-73 ;
WO 2008/040934 A1

68206-45-13-硝基-2-吡啶硫酰氯+

73401-74-84-(羟甲基)苯醋酸

参考文献

Matsueda, Rei; Kaiser, Emil Thomas
Heterocycles, 1981 , vol. 15, # 2 p. 1089 - 1092

73401-74-84-(羟甲基)苯醋酸+

18162-48-6叔丁基二甲基氯硅烷

886363-54-8[4-(叔丁基-二甲基锡氧基甲基)苯基]-乙酸

参考文献

SCHERING CORPORATION
Patent: WO2009/143039 A2, 2009 ;
Location in patent: Page/Page column 124-125 ;
WO 2009/143039 A2

68206-45-13-硝基-2-吡啶硫酰氯+

73401-74-84-(羟甲基)苯醋酸

参考文献

Matsueda, Rei; Kaiser, Emil Thomas
Heterocycles, 1981 , vol. 15, # 2 p. 1089 - 1092

73401-74-84-(羟甲基)苯醋酸+

108-24-7乙酸酐

61165-81-94-[(乙酰氧基)甲基]-苯乙酸

参考文献

Beiersdorf AG; Kolbe, Ludger; Scherner, Cathrin; Ahlheit, Sabrina; Woehrmann, Michael; Mann, Tobias; Gerwat, Wolfram; Schlaeger, Torsten
Patent: US2014/121250 A1, 2014 ;
Location in patent: Paragraph 0064; 0067 ;