N,N-二甲基-1-(2,3,4,9-四氢噻喃并[2,3-b]吲哚-4-基)甲胺合成路线 （共 11 条）
反应条件
sodium hydroxide; formic acid; dimethyl amine in methanol; benzene
参考文献
Shionogi and Co., Ltd.
Patent: US4256640 A1, 1981 ;
反应条件
sodium hydroxide; sodium cyanoborohydride; acetic acid in tetrahydrofuran
参考文献
Shionogi and Co., Ltd.
Patent: US4256640 A1, 1981 ;
反应条件
1: P2S5
2: K2CO3 / acetone / 5 h / Ambient temperature
3: pyridine / 2 h / 100 °C
4: 1) 98 percent HCOOH / 1.) MeOH, RT; 2.) benzene, DMF, reflux, 1 h
View Scheme
参考文献
Takada; Makisumi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 872 - 876
反应条件
1: pyridine / 2 h / 100 °C
2: 1) 98 percent HCOOH / 1.) MeOH, RT; 2.) benzene, DMF, reflux, 1 h
View Scheme
参考文献
Takada; Makisumi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 872 - 876
反应条件
1: K2CO3 / acetone / 5 h / Ambient temperature
2: pyridine / 2 h / 100 °C
3: 1) 98 percent HCOOH / 1.) MeOH, RT; 2.) benzene, DMF, reflux, 1 h
View Scheme
参考文献
Takada; Makisumi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 872 - 876
反应条件
1: pyridine-d5 / 4 h / 100 °C
2: 1) 98 percent HCOOH / 1.) MeOH, RT; 2.) benzene, DMF, reflux, 1 h
View Scheme
参考文献
Takada; Makisumi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 872 - 876
反应条件
1: 87 percent / toluene; pyridine / 1 h / 110 °C
2: 220 mg / methanol / 1 h / -15 °C
3: pyridine-d5 / 4 h / 100 °C
4: 1) 98 percent HCOOH / 1.) MeOH, RT; 2.) benzene, DMF, reflux, 1 h
View Scheme
参考文献
Takada; Makisumi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 872 - 876
反应条件
1: 88 percent / (n-Bu)4NHSO4, NaOH / CH2Cl2 / 0.83 h
2: 97 percent / 46 percent aq.HF / acetonitrile / 2 h
3: 87 percent / toluene; pyridine / 1 h / 110 °C
4: 220 mg / methanol / 1 h / -15 °C
5: pyridine-d5 / 4 h / 100 °C
6: 1) 98 percent HCOOH / 1.) MeOH, RT; 2.) benzene, DMF, reflux, 1 h
View Scheme
参考文献
Takada; Makisumi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 872 - 876
反应条件
1: 220 mg / methanol / 1 h / -15 °C
2: pyridine-d5 / 4 h / 100 °C
3: 1) 98 percent HCOOH / 1.) MeOH, RT; 2.) benzene, DMF, reflux, 1 h
View Scheme
参考文献
Takada; Makisumi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 872 - 876
反应条件
1: 97 percent / 46 percent aq.HF / acetonitrile / 2 h
2: 87 percent / toluene; pyridine / 1 h / 110 °C
3: 220 mg / methanol / 1 h / -15 °C
4: pyridine-d5 / 4 h / 100 °C
5: 1) 98 percent HCOOH / 1.) MeOH, RT; 2.) benzene, DMF, reflux, 1 h
View Scheme
参考文献
Takada; Makisumi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 3 p. 872 - 876
