1: 58 percent / KOH / ethanol; H2O / 16 h / Heating 2: 35 percent / 1) TFA/TFAA 2)p-TsOH / 1) 5h reflux 2) benzene / ethyleneglycol / 24h / reflux ( azeotropic removal of H2O) 3: 1) LDA 2) O2 / THF / HMPA 4: 95 percent / 1N HCl / O2 / acetone / 18 h / Heating 5: 91 percent / K2CO3 / acetone / 14 h / Heating View Scheme