Boc-2-氨基异丁酸酰胺合成路线 （共 5 条）
反应条件
sodium hydroxide in methanol 1.5 h; Ambient temperature;
参考文献
Zanotti; Pinnen
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 8 p. 1629 - 1633
反应条件
1: With pyridine; di-tert-butyl dicarbonate in acetonitrile
T=20°C; 0.333333 h;
2: With ammonia in water; acetonitrile
4.33333 h;
参考文献
F. HOFFMANN-LA ROCHE AG; BISSANTZ, Caterina; GRETHER, Uwe; HEBEISEN, Paul; KIMBARA, Atsushi; LIU, Qingping; NETTEKOVEN, Matthias; PRUNOTTO, Marco; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHULZ-GASCH, Tanja; ULLMER, Christoph; WANG, Zhiwei; YANG, Wulun
Patent: WO2012/168350 A1, 2012 ;
Location in patent: Page/Page column 80 ;
WO 2012/168350 A1
反应条件
pyridine; ammonium hydrogen carbonate in 1,4-dioxane
Heating / reflux; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/17691 A1, 2008 ;
Location in patent: Page/Page column 24 ;
WO 2008/017691 A1
反应条件
1.1: 61 percent / aq. NaOH / dioxane / 3 h / 20 °C
2.1: HOBt; DCC / dimethylformamide; CH2Cl2 / 0.5 h / 20 °C
2.2: 78 percent / aq. ammonium hydroxide / dimethylformamide; CH2Cl2 / 20 °C
View Scheme
参考文献
Rodrigues, Ligia M.; Fonseca, Jose I.; Maia, Hernani L.S.
Tetrahedron, 2004 , vol. 60, # 40 p. 8929 - 8936
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 1 h;
参考文献
Novartis AG
Patent: US6353017 B1, 2002 ;
Location in patent: Page column 27 ;
US 6353017 B1
