5-甲氧基-2-甲苯甲酸甲酯合成路线 （共 15 条）
反应条件
1.1: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C
2.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C
2.2: 0.5 h / |Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C
View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
1.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C
1.2: 0.5 h / |Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C
View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
参考文献
Jacobsen
Chemische Berichte, 1883 , vol. 16, p. 1964
参考文献
Peltier
Bulletin de la Societe Scientifique de Bretagne, 1956 , vol. 31, p. Sonderheft S.9,41
反应条件
1: diethyl ether
2: acetic acid anhydride
3: Raney nickel; methanol / Hydrogenation
4: aqueous HBr; acetic acid
View Scheme
参考文献
Carpenter; Easter
Journal of Organic Chemistry, 1955 , vol. 20, p. 401,407
