5-羟基-2-甲基苯甲酸甲酯合成路线 （共 14 条）
反应条件
sulfuric acid; sodium nitrite Heating;
参考文献
Ray, Sutapa; Patra, Asit; Mal, Dipakranjan
Tetrahedron, 2008 , vol. 64, # 14 p. 3253 - 3267
反应条件
1: With sulfuric acid 3 h; Reflux; 2: With sodium hydroxide in methanol pH=7;
参考文献
BIOGEN IDEC MA INC; PENG, Hairuo; CUERVO, Julio, H.; ISHCHENKO, Alexey; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LUGOVSKOY, Alexey; TALREJA, Tina; TAVERAS, Arthur, G.; XIN, Zhili
Patent: WO2010/138901 A1, 2010 ;
Location in patent: Page/Page column 171-172 ;
WO 2010/138901 A1
反应条件
in methanol; diethyl ether; dichloromethane T=20°C; 72 h;
参考文献
PFIZER JAPAN INC.; HASHIZUME, Yoshinobu; PFIZER INC.
Patent: WO2005/92858 A2, 2005 ;
Location in patent: Page/Page column 99 ;
WO 2005/092858 A2
反应条件
1: With sulfuric acid T=-10°C; Heating; 2: With sodium nitrite in water T=-10 - 100°C; 3: With sulfuric acid in methanol Reflux;
参考文献
EP2103620 A1, ;
Page/Page column 67 ;
反应条件
AlCl3, aluminium chloride in dichloromethane T=0 - 20°C; Diels-Alder reaction; Inert atmosphere; regioselective reaction;
参考文献
Organic and Biomolecular Chemistry, , vol. 6, # 22 p. 4261 - 4270
反应条件
1: 94 percent / H2 / 10percent Pd/C / ethanol / 2 h / 1520 - 2280 Torr 2: 64 percent / 5.4 volpercent H2SO4, aq. NaNO2 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 7 p. 2176 - 2186
反应条件
in trifluoroacetic acid 168 h; Ambient temperature;
参考文献
Schultz, Arthur G.; Antoulinakis, Evan G.
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4555 - 4559
反应条件
trifluoroacetic acid 70 h; Ambient temperature;
参考文献
Schultz, Arthur G.; Harrington, Roger E.; Macielag, Mark; Mehta, Parag G.; Taveras, Arthur G.
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5482 - 5484
反应条件
silica gel T=50°C; 13 h;
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 40, # 11 p. 2240 - 2246
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 11 p. 2565 - 2571
反应条件
Yield given. Multistep reaction;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 23, # 11 p. 1098 - 1102
