6-氯-Alpha-苯基-3-哒嗪乙酰腈合成路线 （共 4 条）
反应条件
1: phenylacetonitrile With potassium hydroxide in dimethyl sulfoxide T=20°C; 0.5 h; 2: 3,6-dichloro-pyridazine in dimethyl sulfoxide T=50°C; 12 h; Further stages.;
参考文献
Herold, Franciszek; Kalucka, Malgorzata; Krol, Marek; Herold, Joanna; Kleps, Jerzy; Turlo, Jadwiga
Molecules, 2007 , vol. 12, # 12 p. 2643 - 2657
反应条件
sodium hydroxide; oxygen; N-benzyl-N,N,N-triethylammonium chloride in dimethyl sulfoxide 3 h; Ambient temperature;
参考文献
Heinisch; Langer
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 6 p. 1685 - 1690
反应条件
1: 66.6 percent / H2, MgO / 10percent Pd/C / ethanol; H2O / 760 Torr / Ambient temperature
2: 41 percent / 48percent hydrobromic acid / 3 h / 110 °C
View Scheme
参考文献
Abbotto, Alessandro; Alanzo, Vito; Bradamante, Silvia; Pagani, Giorgio A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 4 p. 481 - 488
反应条件
1: 95 percent / ammonium formate / 10percent Pd/C / methanol / 48 °C
2: 94 percent / 30percent aq. NaOH, triethylbenzylammonium chloride / methanol / 1.5 h / 45 °C
View Scheme
参考文献
Heinisch; Langer
Synthetic Communications, 1994 , vol. 24, # 6 p. 773 - 778
