5-溴-2,4-二羟基苯酸合成路线 （共 24 条）
反应条件
bromine; acetic acid T=20°C; regioselective reaction;
参考文献
Huang, Zunnan; He, Yantao; Zhang, Xian; Gunawan, Andrea; Wu, Li; Zhang, Zhong-Yin; Wong, Chung F.
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 85 - 99
反应条件
bromine in acetic acid T=25°C; 4 h;
参考文献
Tetrahedron, , vol. 59, # 35 p. 6873 - 6887
反应条件
potassium carbonate in acetone Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44045 A1, 2008 ;
Location in patent: Page/Page column 314 ;
WO 2008/044045 A1
反应条件
1: NaOH-solution / 60 - 70 °C 2: sulfuric acid View Scheme
参考文献
Rice
Journal of the American Chemical Society, 1926 , vol. 48, p. 3127
反应条件
caesium carbonate in N,N-dimethyl-formamide 16 h; Heating / reflux;
参考文献
Merck Patent Gesellschaft
Patent: US2010/113542 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
sodium hydroxide T=60 - 70°C;
参考文献
Rice
Journal of the American Chemical Society, 1926 , vol. 48, p. 3127
参考文献
Rice
Journal of the American Chemical Society, 1926 , vol. 48, p. 3127
反应条件
thionyl chloride T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 16 p. 5956 - 5969
反应条件
potassium hydroxide in tetrahydrofuran; diethyl ether; water T=0°C;
参考文献
WO2007/139955 A2, ;
Page/Page column 226-227 ;
参考文献
Journal of the Indian Chemical Society, , vol. 30, p. 373,377
Journal of the Indian Chemical Society, , vol. 31, p. 600,603
