2-氨基-4-羟基吡咯并[2,3-d]嘧啶合成路线 （共 26 条）
反应条件
in water; N,N-dimethyl-formamide T=20°C; 46 h;
参考文献
Klepper, Florian; Jahn, Eva-Maria; Hickmann, Volker; Carell, Thomas
Angewandte Chemie - International Edition, 2007 , vol. 46, # 13 p. 2325 - 2327
反应条件
1: 2-bromoacetaldehyde diethyl acetal With hydrogenchloride in water T=90°C; 0.5 h; 2: With sodium acetate in water T=20°C; 3: 2,4-diamino-6(1H)-pyrimidone in water T=80°C; 2 h;
参考文献
Brueckl, Tobias; Thoma, Ines; Wagner, Andreas J.; Knochel, Paul; Carell, Thomas
European Journal of Organic Chemistry, 2010 , # 34 p. 6517 - 6519
反应条件
hydrogenchloride T=20°C; 1 h;
参考文献
Tsytovich, A. V.; Shamshin, D. V.; Burkovskii, V. B.; Shvets, V. I.
Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 11 p. 756 - 761
Bioorganicheskaya Khimiya, 1995 , vol. 21, # 11 p. 874 - 880
反应条件
sodium acetate in water T=85°C;
参考文献
Wilding, Birgit; Winkler, Margit; Petschacher, Barbara; Kratzer, Regina; Glieder, Anton; Klempier, Norbert
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2191 - 2198
反应条件
sodium hydroxide in methanol 3 h; Heating;
参考文献
Seela, Frank; Kehne, Andreas; Winkeler, Heinz-Dieter
Liebigs Annalen der Chemie, 1983 , # 1 p. 137 - 146
参考文献
Han, Bo; Rajwanshi, Vivek; Nandy, Jyoti; Krishnamurthy, Ramanarayanan; Eschenmoser, Albert
Synlett, 2005 , # 5 art. no. S10704ST, p. 744 - 750
反应条件
1: 82 percent / EtONa / ethanol / 6 h / Heating 2: 88 percent / 0.2N aq. HCl / 1 h / 20 °C View Scheme
参考文献
Russian Journal of Bioorganic Chemistry, , vol. 21, # 11 p. 756 - 761
Bioorganicheskaya Khimiya, , vol. 21, # 11 p. 874 - 880
反应条件
water; sodium acetate in 1,4-dioxane regiospecific reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 132 - 137
反应条件
hydrogenchloride in water T=25°C; Rate constant;
参考文献
Helvetica Chimica Acta, , vol. 69, # 7 p. 1602 - 1613
反应条件
1.1: trichlorophosphate / 3 h / Reflux 1.2: 20 °C / pH 2 / Cooling with ice 2.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C 2.2: 2 h / 0 - 80 °C 2.3: pH 8 View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VAN CAMP, Jennifer; XU, Xiangdong; OSUMA, Augustine, Toby; GREGG, Robert; LONGENECKER, Kenton, L.
Patent: WO2012/45195 A1, 2012 ;
WO 2012/045195 A1
