3-硝基-4-甲基苯甲酸甲酯合成路线 （共 22 条）
反应条件
1: 97 percent / dimethylformamide / 2 h / 130 °C 2: 85 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.58 h / 2585.7 Torr 3: 95 percent / aq. LiOH / tetrahydrofuran; methanol / 6 h / 60 °C View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
反应条件
1: 99 percent / tetrahydrofuran / 2 h / 140 °C 2: 95 percent / NaIO4 / tetrahydrofuran; H2O / 2 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 2 p. 219 - 222
反应条件
1: NBS, benzoylperoxide / CCl4 / 5 h / Heating
2: 35 percent / 0.2 N NaOH / methanol / 20 °C
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: NBS, benzoylperoxide / CCl4 / 5 h / Heating
2: 35 percent / 0.2 N NaOH / methanol / 20 °C
3: 95 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
2: 83 percent / 2,6-lutidine / benzene
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
2: 83 percent / 2,6-lutidine / benzene
3: 80 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: NBS, benzoylperoxide / CCl4 / 5 h / Heating
2: 35 percent / 0.2 N NaOH / methanol / 20 °C
3: 95 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
4: 64 percent / 2,6-lutidine / benzene
5: 78 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: NBS, benzoylperoxide / CCl4 / 5 h / Heating
2: 35 percent / 0.2 N NaOH / methanol / 20 °C
3: 95 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
4: 64 percent / 2,6-lutidine / benzene
5: 78 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
6: 90 percent / water, NaOH / pyridine; methanol / 24 h / Heating
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
2: 83 percent / 2,6-lutidine / benzene
3: 80 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
4: 41 percent / water, NaOH / pyridine; methanol / 24 h / Heating
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: NBS, benzoylperoxide / CCl4 / 5 h / Heating
2: 35 percent / 0.2 N NaOH / methanol / 20 °C
3: 95 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
4: 64 percent / 2,6-lutidine / benzene
5: 78 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
6: 90 percent / water, NaOH / pyridine; methanol / 24 h / Heating
7: 48 percent / BBr3 / CH2Cl2 / 24 h / -35 °C
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
