2-氯-6-甲氧基喹啉-3-甲醛合成路线 （共 15 条）
反应条件
hydroxylamine hydrochloride; sodium acetate in methanol T=35°C; 0.333333 h;
参考文献
Bhat, Neelima Balkrishen; Bhaduri, A.P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 5 p. 431 - 434
反应条件
formic acid; triethylamine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=110°C;
参考文献
Sato, Itaru; Nakao, Tomohiko; Sugie, Rie; Kawasaki, Tsuneomi; Soai, Kenso
Synthesis, 2004 , # 9 p. 1419 - 1428
反应条件
bromine in various solvent(s) T=120 - 130°C; 0.5 h;
参考文献
Synthetic Communications, , vol. 21, # 18-19 p. 1929 - 1934
反应条件
acetic acid in water 8 h; Reflux;
参考文献
CENTRO CARDIOLOGICO MONZINO SpA; Abbracchio, Mariapia; Eberini, Ivano; Parravicini, Chiara; Martini, Claudia; Trincavelli, Maria Letizia; Daniele, Simona
Patent: US2014/148472 A1, 2014 ;
Location in patent: Paragraph 0050-0051 ;
反应条件
1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C
2: thionyl chloride; pyridine / benzene / 2 h / 0 - 80 °C
View Scheme
参考文献
Mareddy, Jyoti; Shanthi Praveena, Koduru Sri; Suresh, Nallapati; Jayashree, Anireddy; Roy, Soma; Rambabu, Dandela; Sreenivasa Murthy, Nandula Yadagiri; Pal, Sarbani
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 343 - 352
