7-氯-2-羟基喹啉-3-甲醛合成路线 （共 4 条）
反应条件
PPA
T=140 - 150°C; 0.166667 h;
参考文献
Meth-Cohn, Otto; Narine, Bramha; Tarnowski, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1520 - 1530
反应条件
1.1: trichlorophosphate / 0.08 h / 0 - 5 °C
1.2: 8 h / 75 - 80 °C
2.1: acetic acid / water / 4 h / Reflux
View Scheme
参考文献
Parmar, Narsidas J.; Barad, Hitesh A.; Pansuriya, Bhavesh R.; Teraiya, Shashikant B.; Gupta, Vivek K.; Kant, Rajni
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3816 - 3821
反应条件
1: aq. 20percent sodium hydroxide / ethanol; H2O / 0.02 h / Heating
2: 98 percent / polyphosphoric acid / 0.17 h / 140 - 150 °C
View Scheme
参考文献
Meth-Cohn, Otto; Narine, Bramha; Tarnowski, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1520 - 1530
反应条件
1: 1.) KOH / 1.) MeOH, heating; 2.) MeOH, 3 h, heating
2: 90 percent / NH2OH*HCl, 4 M NaOH / ethanol; H2O / 1 h / Heating
3: 90 percent / Ac2O / 2 h / Heating
View Scheme
参考文献
Raj, T. Tilak; Ambekar, Sarvottam Y.
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 2 p. 293 - 298
