in ethanol Heating;

(i) Na, EtOH, (ii) /BRN= 105107/; Multistep reaction;

hydrogen fluoride T=5 - 12°C; 4.58333 h; electrochemical fluorination: nickel electrodes, anodic current density: 3.6 A/dm2, cell voltage 6.1 - 8.1 V;

potassium carbonate in N,N-dimethyl-formamide T=80°C; 12 h;

1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C 2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 3.1: 349 g / acetic anhydride / 3 h / 110 °C 4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 86 percent / HCl / H2O / 90 - 130 °C 6.1: thionyl chloride / dimethylformamide / 2 h / Heating 6.2: 73 percent / dimethylformamide / 1 h / 100 °C View Scheme

1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C 2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 3.1: 349 g / acetic anhydride / 3 h / 110 °C 4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme

hydrogen fluoride T=5 - 12°C; 4.58333 h; electrochemical fluorination: nickel electrodes, anodic current density: 3.6 A/dm2, cell voltage 6.1 - 8.1 V;

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 90 °C 2: hydrogen / palladium on activated charcoal / methanol View Scheme

暂无反应条件数据

in N-methyl-acetamide; water; toluene