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乙二醇
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63148-62-9
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碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-氯-4-溴吡啶
合成路线
（共 28 条）
14432-12-3
2-氯-4-氨基吡啶
→
反应条件
73583-37-6
2-氯-4-溴吡啶
反应条件
1: With hydrogen bromide; sodium nitrite in water 2: With potassium bromide in water Sandmeyer bromination;
参考文献
Chung, John Y. L.; Cvetovich, Raymond J.; McLaughlin, Mark; Amato, Joseph; Tsay, Fuh-Rong; Jensen, Mark; Weissman, Steve; Zewge, Daniel
Journal of Organic Chemistry, 2006 , vol. 71, # 22 p. 8602 - 8609
52200-48-3
3-溴-2-氯吡啶
→
反应条件
73583-37-6
2-氯-4-溴吡啶
反应条件
bromine; tert.-butyl lithium; diisopropylamine 1.) THF, -60 deg C, 2.) -70 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Journal of Organometallic Chemistry, , vol. 382, # 3 p. 319 - 332
2402-95-1
2-氯吡啶-N-氧化物
→
反应条件
73583-37-6
2-氯-4-溴吡啶
反应条件
1: concentrated sulfuric acid; nitric acid 2: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 3: sodium nitrite; aqueous sulfuric acid; copper (II)-sulfate; potassium bromide / 60 °C / Diazotization.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser View Scheme
参考文献
Roczniki Chemii, , vol. 29, p. 1019,1025
Chem.Abstr., , p. 12045
14432-16-7
2-氯-4-硝基吡啶 N-氧化物
→
反应条件
73583-37-6
2-氯-4-溴吡啶
反应条件
1: acetic acid; iron-powder / anschliessend mit Zink-Pulver unter Zusatz von wenig wss. HgCl2 2: sodium nitrite; aqueous sulfuric acid; copper (II)-sulfate; potassium bromide / 60 °C / Diazotization.Reagens 4: Kupfer-Pulver; Reagens 5: Wasser View Scheme
参考文献
Roczniki Chemii, , vol. 29, p. 1019,1025
Chem.Abstr., , p. 12045
73583-37-6
2-氯-4-溴吡啶
+
79-22-1
氯甲酸甲酯
→
反应条件
1064678-14-3
反应条件
1: 4-bromo-2-chloro-pyridine With lithium diisopropyl amide in tetrahydrofuran T=-85 - -80°C; 0.5 h; 2: methyl chloroformate in tetrahydrofuran T=-80°C; 0.833333 h;
参考文献
Gibson, Christoph; Schnatbaum, Karsten; Pfeifer, Jochen R.; Locardi, Elsa; Paschke, Matthias; Reimer, Ulf; Richter, Uwe; Scharn, Dirk; Faussner, Alexander; Tradler, Thomas
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4370 - 4379
73583-37-6
2-氯-4-溴吡啶
+
68-12-2
N,N-二甲基甲酰胺
→
反应条件
36404-88-3
2-氯-3-吡啶甲醛
反应条件
Yield given. Multistep reaction;
参考文献
Mallet, Marc; Branger, Gilles; Marsais, Francis; Queguiner, Guy
Journal of Organometallic Chemistry, 1990 , vol. 382, # 3 p. 319 - 332
73583-37-6
2-氯-4-溴吡啶
+
24388-23-6
苯硼酸频哪醇酯
→
反应条件
42260-39-9
2-氯-4-苯基吡啶
反应条件
potassium phosphate; (C5H5FeC5H3C(CH3)NC6H4CH3)PdCl(tricyclohexylphosphine); potassium acetate in 1,4-dioxane; water T=100°C; Suzuki coupling; 15 h; Inert atmosphere;
参考文献
Wang, Lianhui; Cui, Xiuling; Li, Jingya; Wu, Yusheng; Zhu, Zhiwu; Wu, Yangjie
European Journal of Organic Chemistry, 2012 , # 3 p. 595 - 603
73583-37-6
2-氯-4-溴吡啶
→
反应条件
42260-39-9
2-氯-4-苯基吡啶
反应条件
1: (C5H5FeC5H3C(CH3)NC6H4CH3)PdCl(tricyclohexylphosphine); potassium acetate / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere 2: potassium phosphate; (C5H5FeC5H3C(CH3)NC6H4CH3)PdCl(tricyclohexylphosphine); potassium acetate / 1,4-dioxane; water / 15 h / 100 °C / Inert atmosphere View Scheme
参考文献
Wang, Lianhui; Cui, Xiuling; Li, Jingya; Wu, Yusheng; Zhu, Zhiwu; Wu, Yangjie
European Journal of Organic Chemistry, 2012 , # 3 p. 595 - 603
73583-37-6
2-氯-4-溴吡啶
→
反应条件
174482-98-5
(试剂)4-(2-CHLOROISONICOTINOYL)MORPHOLINE
反应条件
1: zinc; lithium chloride / 2 h / 20 °C / |Inert atmosphere 2: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Shin, Ueon Sang; Cho, Kyung-Hwan; Kim, Seung-Hoi
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 5 p. 1575 - 1578
73583-37-6
2-氯-4-溴吡啶
→
反应条件
458532-96-2
2-氯-4-吡啶硼酸
反应条件
1: With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether T=-60°C; 0.5 h; 2: With tri-isopropoxy-borane in diethyl ether T=-70 - 20°C; 3: With sodium hydroxide in diethyl ether; water
参考文献
Tetrahedron, , vol. 58, # 22 p. 4369 - 4373
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