1: 99.4 percent / CH2Cl2 / 6.3 h / Ambient temperature 2: 56 percent / thionyl chloride / CH2Cl2; dimethylformamide / 4 h / 25 °C 3: 95.5 percent / hydrogen, triethylamine / 5percent Pd/C / ethyl acetate / 4.5 h / Ambient temperature 4: 283 mg / liq. ammonia / 96 h / Ambient temperature View Scheme

1: 87 percent / manganese dioxide / toluene / 1.) reflux, 3 h, 2.) heating, 5 h 2: 99.4 percent / CH2Cl2 / 6.3 h / Ambient temperature 3: 56 percent / thionyl chloride / CH2Cl2; dimethylformamide / 4 h / 25 °C 4: 95.5 percent / hydrogen, triethylamine / 5percent Pd/C / ethyl acetate / 4.5 h / Ambient temperature 5: 283 mg / liq. ammonia / 96 h / Ambient temperature View Scheme

1: 56 percent / thionyl chloride / CH2Cl2; dimethylformamide / 4 h / 25 °C 2: 95.5 percent / hydrogen, triethylamine / 5percent Pd/C / ethyl acetate / 4.5 h / Ambient temperature 3: 283 mg / liq. ammonia / 96 h / Ambient temperature View Scheme

1: 95.5 percent / hydrogen, triethylamine / 5percent Pd/C / ethyl acetate / 4.5 h / Ambient temperature 2: 283 mg / liq. ammonia / 96 h / Ambient temperature View Scheme

1: (CF3CO)2O; pyridine / tetrahydrofuran / -10 °C 2: NEt3 / methanol View Scheme

1: 86 percent / (CF3CO)2O; pyridine / tetrahydrofuran / 0.13 h / 5 °C 2: 77 percent / NH3 / 17 h / 100 °C View Scheme

1: 54.3 percent / conc. ammonium hydroxide / 8 h / Ambient temperature 2: 78.3 percent / phosphoryl chloride / 1.5 h / Heating 3: 1.) hexamethyldisilazane, ammonium sulfate; 2.) stannic chloride / 1.) reflux, 15 h; 2.) 1,2-dichloroethane, 20 h, r.t. 4: 37 percent / liquid ammonia / 15 h / 100 °C / in a steel bomb View Scheme

1: 1.) hexamethyldisilazane, ammonium sulfate; 2.) stannic chloride / 1.) reflux, 15 h; 2.) 1,2-dichloroethane, 20 h, r.t. 2: 37 percent / liquid ammonia / 15 h / 100 °C / in a steel bomb View Scheme

1: 1.) hexamethyldisilazane, ammonium sulfate; 2.) stannic chloride / 1.) reflux, 15 h; 2.) 1,2-dichloroethane, 20 h, r.t. 2: 37 percent / liquid ammonia / 15 h / 100 °C / in a steel bomb View Scheme

1: 78.3 percent / phosphoryl chloride / 1.5 h / Heating 2: 1.) hexamethyldisilazane, ammonium sulfate; 2.) stannic chloride / 1.) reflux, 15 h; 2.) 1,2-dichloroethane, 20 h, r.t. 3: 37 percent / liquid ammonia / 15 h / 100 °C / in a steel bomb View Scheme