1: With diphenylphosphoranyl azide; triethylamine in tetrahydrofuran
T=25°C; Curtius rearrangement; 3 h;
2: With water in tetrahydrofuran
2 h; Heating;
参考文献
Tichenor, Mark S.; Trzupek, John D.; Kastrinsky, David B.; Shiga, Futoshi; Hwang, Inkyu; Boger, Dale L.
Journal of the American Chemical Society, 2006 , vol. 128, # 49 p. 15683 - 15696
1.1: 88 percent / K2CO3 / dimethylformamide / 14 h / 25 °C
2.1: 97 percent / aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 12 h / 25 °C
3.1: diphenylphosphoryl azide; Et3N / tetrahydrofuran / 3 h / 25 °C
3.2: 78 percent / H2O / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Tichenor, Mark S.; Trzupek, John D.; Kastrinsky, David B.; Shiga, Futoshi; Hwang, Inkyu; Boger, Dale L.
Journal of the American Chemical Society, 2006 , vol. 128, # 49 p. 15683 - 15696
1.1: 97 percent / aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 12 h / 25 °C
2.1: diphenylphosphoryl azide; Et3N / tetrahydrofuran / 3 h / 25 °C
2.2: 78 percent / H2O / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Tichenor, Mark S.; Trzupek, John D.; Kastrinsky, David B.; Shiga, Futoshi; Hwang, Inkyu; Boger, Dale L.
Journal of the American Chemical Society, 2006 , vol. 128, # 49 p. 15683 - 15696
1.1: 88 percent / K2CO3 / dimethylformamide / 14 h / 25 °C
2.1: 97 percent / aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 12 h / 25 °C
3.1: diphenylphosphoryl azide; Et3N / tetrahydrofuran / 3 h / 25 °C
3.2: 78 percent / H2O / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Tichenor, Mark S.; Trzupek, John D.; Kastrinsky, David B.; Shiga, Futoshi; Hwang, Inkyu; Boger, Dale L.
Journal of the American Chemical Society, 2006 , vol. 128, # 49 p. 15683 - 15696
