4-氯-alpha-苯基苄基(甲基)醚合成路线 （共 11 条）
反应条件
1: benzyl methyl ether With 2,3-dicyano-5,6-dichloro-p-benzoquinone in chlorobenzene
T=80°C; 1.5 h; Inert atmosphere;
2: 4-chlorophenyl-magnesium bromide in chlorobenzene
T=0°C; 3 h; Inert atmosphere;
参考文献
Muramatsu, Wataru; Nakano, Kimihiro; Li, Chao-Jun
Organic Letters, 2013 , vol. 15, # 14 p. 3650 - 3653
反应条件
1: 1-chloro-4-(methoxymethyl)benzene With 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-[(trifluoroacetoxy)iodo]benzene in 1,2-dichloro-ethane
T=80°C; 3 h; Inert atmosphere;
2: PhMgI in diethyl ether; 1,2-dichloro-ethane
T=-20°C; 3 h; Inert atmosphere;
参考文献
Muramatsu, Wataru; Nakano, Kimihiro
Organic Letters, 2014 , vol. 16, # 7 p. 2042 - 2045
反应条件
1: SOCl2
2: methanol
View Scheme
参考文献
Zee-Cheng,K.Y.; Cheng,C.C.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1008 - 1015
反应条件
molybdenum peroxide hexamethylphosphorylamide in methanol
Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Kawasaki, Tomomi; Hoshi, Ryuichi; Yamamoto, Toshihiko; Satoh, Kazue; Sakamoto, Masanori
ACH - Models in Chemistry, 1998 , vol. 135, # 4 p. 565 - 572
参考文献
Zee-Cheng,K.Y.; Cheng,C.C.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1008 - 1015
反应条件
water in acetonitrile
T=25°C; product selectivity; var. conc. of reactants; Rate constant;
参考文献
Bentley, T. William; Ryu, Zoon Ha
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 4 p. 761 - 768
反应条件
potassium chloride
T=35°C; also with CH3OD; Rate constant;
参考文献
Chang, Saemin; Koh, Han Joong; Lee, Bon-Su; Lee, Ikchoon
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7760 - 7768
反应条件
molybdenum peroxide hexamethylphosphorylamide
Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Kawasaki, Tomomi; Hoshi, Ryuichi; Yamamoto, Toshihiko; Satoh, Kazue; Sakamoto, Masanori
ACH - Models in Chemistry, 1998 , vol. 135, # 4 p. 565 - 572
反应条件
in cyclohexane
T=26.9°C; Irradiationother solvent (isooctane); Rate constant;
参考文献
Hadel, L. M.; Maloney, V. M.; Platz, M. S.; McGimpsey, W. G.; Scaiano, J. C.
Journal of Physical Chemistry, 1986 , vol. 90, # 11 p. 2488 - 2491
反应条件
(i) I2, (ii) aq. Na2S2O3; Multistep reaction;
参考文献
Rutherford,K.G. et al.
Canadian Journal of Chemistry, 1966 , vol. 44, p. 2337 - 2339
