potassium tert-butylate in tetrahydrofuran 0.0833333 h; Ambient temperature;

1: 30percent hydrogen peroxide / ethanol / 60 °C 2: CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temperature, 15 min 3: KCN, sodium acetate, pH 4.0 / CH2Cl2; H2O / 0.25 h 4: 50 percent / potassium tert-butoxide / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme

1: NaBH4 / methanol / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h 2: 30percent hydrogen peroxide / ethanol / 60 °C 3: CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temperature, 15 min 4: KCN, sodium acetate, pH 4.0 / CH2Cl2; H2O / 0.25 h 5: 50 percent / potassium tert-butoxide / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme

1: CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temperature, 15 min 2: KCN, sodium acetate, pH 4.0 / CH2Cl2; H2O / 0.25 h 3: 50 percent / potassium tert-butoxide / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme